Spasmolytic Action of 4-Methylumbelliferone in Isolated Guinea-Pig’s Gallbladder
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چکیده
منابع مشابه
Spasmolytic activity of a herbal drug isolated from Tephrosia purpurea in guinea pigs
We investigated the spasmolytic activity of herbal drugs isolated from Tephrosia purpurea on guinea pigs for the treatment of asthma in India. For this investigation, the herbal drug was extracted with 70% ethanol in soxhlet apparatus. After purification and isolution, the drug was used in experimental animals to observe prophylactic activity. For anaphylactic activity, horse serum 0.5 ml along...
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Background: Several therapeutic effects including anti-asthma and dyspnea have been described for Plantago lanceolata. In the present study the antitussive effect of this plant was evaluated. Methods: The antitussive effects of aerosols of two different concentrations of Soxhlet and macerated ethanolic extracts, codeine and saline were tested by counting the number of coughs produced due to aer...
متن کاملRole of PGE2 on gallbladder muscle cytoprotection of guinea pigs.
H2O2 and taurochenodeoxycholic acid (TCDC) impair the contraction induced by CCK-8, ACh, and KCl without affecting the actions of PGE2 and damage functions of membrane proteins except for PGE2 receptors. The aim of this study was to examine whether the preserved PGE2 actions contribute to cytoprotective mechanisms against reactive oxygen species. Muscle cells from guinea pig gallbladder were ob...
متن کاملAntitussive Effect of Rosa damascena in Guinea pigs
Several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of Rosa damascena. North American Indian tribes use a decoction of the roots obtained from the Rosa damascena plant as a cough remedy and to treat eye problem. Therefore, in the present study the antitussive effect of this plant in ...
متن کامل[Sites of action of CCK of the guinea pig gallbladder].
Cholecystokinin-octapeptide (CCK-OP) evoked contraction and 3H-acetylcholine (3H-ACh) release of the muscle strip of the guinea pig gallbladder were studied. Although hexamethonium (10(-5) M) or tetrodotoxin (10(-6) M) had no effect on CCK-OP (10(-8) M) evoked contraction and 3H-ACh release, Ca-free medium almost completely abolished CCK-OP (10(-8) M) evoked 3H-ACh release. In Ca-free medium co...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1971
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)36182-7